If you want to come to Aydin with your private car, you can enter Aydin city from many points. You can reach Aydin from Izmir, Denizli, Manisa and Muğla within a few hours. If you want to reach Aydın by main road (approximately 600 km) from Istanbul, a 7-8 hour journey will be waiting for you. To reach Aydın from Ankara by main road (approximately 550 km), you need to travel 6-7 hours. If you want to reach Aydin by bus, there are direct bus services to Aydin from almost every city.
For detailed information: http://www.kgm.gov.tr/Sayfalar/KGM/SiteTr/Bolgeler/2Bolge/BolgedekiIller.aspx